Overview
- Mainz will host AC Fiorentina, Samsunspor and Zrinjski Mostar in the ligaphase.
- Away fixtures are at Lech Poznań, Universitatea Craiova and Omonia Nicosia.
- The 36-team ligaphase gives each club six single-round games against different opponents; the top eight advance to the round of 16, places 9–24 enter play-offs, and 25–36 are eliminated.
- Matchdays run on 2 Oct, 23 Oct, 6 Nov, 27 Nov, 11 Dec and 18 Dec 2025.
- UEFA will confirm exact pairings and kick-off times shortly, and the final is scheduled for 27 May 2026 in Leipzig.