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Mail-In Self-Collection HPV Tests Double Screening Rates Among Underserved Women

The PRESTIS trial results underpin the FDA’s May approval of the first at-home cervical cancer screening test.

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Overview

  • In the PRESTIS study, 41% of under-screened women who received mailed kits and telephone reminders completed screening within six months versus 17% with reminders alone.
  • Adding patient navigation support alongside mailed self-collection kits and reminders boosted participation to 47%.
  • Over 80% of women in the self-collection groups returned their kits, demonstrating strong acceptance of home testing.
  • The trial enrolled nearly 2,500 women aged 30 to 65 in the Houston area, with 94% from racial or ethnic minoritized groups and 56% covered by public assistance.
  • Researchers intend to integrate self-collection HPV testing into diverse primary care settings to further reduce screening disparities.