Overview

• Health agencies including the Deutsche Hochdruckliga now recognize magnesium supplementation of up to 250 mg per day as a safe and cost-effective adjunct to standard antihypertensive regimens.
• Clinical trials show that 360 mg of magnesium daily can reduce diastolic pressure by about 10 mmHg, leading to therapeutic dose guidelines between 300 and 600 mg under supervision.
• Magnesium lowers blood pressure by acting as a natural calcium antagonist and promoting vascular relaxation, while deficiency is linked to elevated hypertension risk.
• Oral doses above 250 mg without monitoring may cause gastrointestinal side effects such as diarrhea, with serious toxicity only reported at extreme intakes near 2,500 mg daily.
• Patients with impaired renal function require adjusted dosing and regular magnesium level checks to prevent hypermagnesemia.