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Machine Perfusion Extends Donor Heart Viability, Enabling Long-Distance and International Transplants

St. Vincent's Hospital in Sydney has pioneered the use of normothermic machine perfusion, preserving donor hearts for up to ten hours and expanding transplant logistics across Australia and potentially to the Pacific and Asia.

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Overview

  • Machine perfusion technology now allows donor hearts to remain viable for up to eight to ten hours, surpassing the traditional six-hour limit of cold storage.
  • St. Vincent’s Hospital in Sydney has used this technology since 2014 and now employs it in over half of its heart transplants, particularly for circulatory-death donor hearts.
  • The extended preservation window has removed time constraints for cross-country heart transport, enabling transplants between distant Australian cities like Perth and Sydney.
  • Research confirms that heart transplants using machine perfusion achieve outcomes comparable to those using traditional methods, maintaining primary graft function effectively.
  • The technology opens possibilities for international organ sharing, with Australia already collaborating with New Zealand and exploring retrieval opportunities in the Pacific Islands and Asia.