Overview

• Head coach Kyle Shanahan said it is “highly unlikely” Brock Purdy starts, so Mac Jones will open at quarterback.
• Purdy is listed as questionable after three limited practices while managing a toe injury and a non-throwing shoulder issue.
• A Saturday call will determine whether Purdy dresses as the No. 2 or serves only as the emergency No. 3, according to NFL Network reporting.
• If Purdy is inactive, practice-squad quarterback Adrian Martinez is expected to be elevated to back up Jones; if Purdy is the emergency option, Martinez would need a 53-man roster spot under NFL rules.
• San Francisco ruled out G Spencer Burford (knee) and rookie WR Jordan Watkins (calf), with LG Connor Colby and WR Jauan Jennings questionable, tightening offensive depth for the divisional game.