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1h ago

Mac Jones Starts With Purdy Out as Rams Host 49ers for NFC West Lead

A rash of 49ers injuries has shifted betting lines toward Los Angeles ahead of the 8:15 p.m. ET kickoff.

Image
Sep 28, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) runs the ball during the first half against the Jacksonville Jaguars at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images/ File Photo
Los Angeles Rams linebacker Jared Verse, left, and linebacker Byron Young celebrate a tackle during the first half on Sept. 21 in Philadelphia. 
49ers quarterback Mac Jones will face a fierce Rams pass rush while dealing with a nagging knee injury that requires a brace, limiting his mobility. 

Overview

  • San Francisco officially ruled out QB Brock Purdy (toe) and WRs Ricky Pearsall (knee) and Jauan Jennings (ankle/ribs), naming Mac Jones the starter.
  • The 49ers also remain without TE George Kittle (injured reserve) and DE Nick Bosa (season-ending knee), further depleting key units.
  • The Rams listed TE Tyler Higbee (hip) and RT Rob Havenstein (ankle) as doubtful after not practicing this week.
  • Sportsbooks lengthened the spread toward Los Angeles, with lines moving from roughly Rams -3 to about a touchdown or more following San Francisco’s final injury report.
  • Expert pick aggregates largely back the Rams at home, with both teams 3-1 and the winner set to take sole possession of the NFC West lead at SoFi Stadium.