Luxembourg's Prince Frederik Dies at 22 After Battle with Rare Genetic Disease

The young royal, known for his humor and compassion, passed away surrounded by family after a lifelong fight with POLG Mitochondrial disease.

Prince Frederik of Luxembourg, the youngest son of Prince Robert and Princess Julie, passed away on March 1 at the age of 22 due to POLG Mitochondrial disease.
Diagnosed at age 14, the rare genetic condition disrupts cellular energy production, leading to progressive organ dysfunction and failure.
Frederik spent his final moments with his family, offering heartfelt goodbyes and sharing a family joke to lighten the mood.
His father, Prince Robert, described Frederik as a superhero and praised his positivity, humor, and determination throughout his life.
Frederik founded the POLG Foundation to raise awareness and support research for the disease, and his family has encouraged donations to honor his legacy.