Overview

• No. 3 Oregon hosts No. 7 Indiana in a Heisman-spotlight quarterback duel, with sportsbooks holding the Ducks around a touchdown favorite and SportsLine simulations backing Oregon to cover.
• The Red River Rivalry line swung from Texas -3 to a slight Oklahoma edge after Sooners quarterback John Mateer, less than three weeks post hand surgery, was upgraded late in the week to probable.
• Both Oregon and Indiana enter 5-0 and tied with No. 1 Ohio State atop the Big Ten standings, positioning the winner for a clearer College Football Playoff path.
• AP previews flag multiple ranked matchups as poll-shifting, including No. 1 Ohio State at No. 17 Illinois and No. 8 Alabama at No. 14 Missouri, with BetMGM listing OSU -14.5 and Alabama -3.
• Models and experts diverge on several games, but consensus indicators highlight Oregon’s 18-game home win streak at Autzen as a key factor in Saturday’s marquee clash.