Overview

• A single low-intensity rTMS session boosted terminaux bouton turnover in both APP/PS1 Alzheimer’s model and wild-type mice, according to a Neurophotonics study.
• Turnover of local synaptic endings surged by 88% in healthy mice and 213% in Alzheimer’s model mice two days after stimulation before returning to baseline by day eight.
• The stimulation selectively enhanced dynamics of terminaux boutons without altering en passant bouton turnover, indicating bouton-type specificity.
• Researchers used live two-photon microscopy to image individual axonal boutons every 48 hours over an eight-day period surrounding the rTMS session.
• These mechanistic insights underpin the rationale for optimizing targeted rTMS protocols as the therapy advances into human Alzheimer’s trials.