Overview
- Brown suffered the leg injury late in the Week 10 win at Virginia Tech after rushing for 130 yards, including a 52-yard touchdown.
 - Brohm confirmed Brown will be sidelined for at least Week 11 against California and declined to rule out a regular-season return.
 - The Cardinals are expected to elevate Keyjuan Brown to lead back duties after his late clinching runs versus Virginia Tech and Boston College.
 - Keyjuan Brown has produced 321 rushing yards and six touchdowns in seven games, giving Louisville a proven short-term option.
 - Isaac Brown leads the nation at 8.6 yards per carry with 782 yards on 91 attempts, and his absence factors into Louisville's ACC push with a noted road test at SMU on Nov. 22.