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9h ago

Louisville's Isaac Brown Out 'for a While' With Leg Injury, Will Miss Cal

Coach Jeff Brohm stopped short of declaring the season over, leaving Louisville to elevate Keyjuan Brown at running back.

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals running back Isaac Brown (1) reacts after scoring a touchdown against the Virginia Tech Hokies during the first quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images
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Overview

  • Brown exited in the second half of the 28-16 win at Virginia Tech, which moved Louisville to 7-1 and up to No. 14 in the AP poll.
  • Brohm said Brown is out for a while and at least unavailable for Week 11 against California while not ruling out a regular-season return.
  • The sophomore has 782 rushing yards on 91 carries with a nation-leading 8.6 yards per attempt and five touchdowns.
  • Keyjuan Brown is expected to take primary snaps after two touchdowns against Virginia Tech, bringing his season totals to 321 yards and six scores.
  • The absence reshapes Louisville’s push for the ACC title and CFP positioning with home games ahead before a Nov. 22 trip to SMU, cited as the toughest remaining test.