Overview

• Lousiville's Isaac Brown rushed for a career-high 151 yards, including a decisive 45-yard touchdown in the fourth quarter.
• Quarterback Tyler Shough contributed with a somersault touchdown and led the Cardinals to a 33-21 victory.
• The win marked Louisville's first-ever victory over Clemson since joining the Atlantic Coast Conference nine years ago.
• Clemson's offense struggled to capitalize on their 450 total yards, hindered by two blocked field goal attempts.
• The defeat significantly impacts Clemson's chances for an ACC title and a College Football Playoff spot, requiring outside help to advance.