Overview
- Monitoring nearly 150 adults across 10 U.S. centers for up to three years, the Human Epilepsy Project reported in JAMA Neurology on Oct. 20 that roughly 68–70% saw declines in average monthly seizures.
- A subset achieved sustained seizure-free periods, with about 13% reaching at least three months, nearly 8% at six months, and 3% at 12 months or longer.
- More than half of participants who improved had started a new anti-seizure medication during the study, yet the number of previously failed drugs did not predict later reduction.
- Electronic seizure diaries captured real-world patterns during ongoing treatment changes, so investigators caution that improvements may reflect either management effects or the natural course of refractory epilepsy.
- The project plans to assess generalized epilepsy next, with the study disclosing support from UCB, Neurelis, and SK Life Science.