Overview

• In a Science Advances paper, researchers fed male and female mice a roughly 90% fat ketogenic diet for nearly a year and compared outcomes with three other diets.
• The keto group initially lost weight, then developed fatty liver, hyperlipidemia, extreme glucose intolerance, and impaired insulin secretion.
• Male mice exhibited more severe effects in some measures, including higher cholesterol and hepatic steatosis.
• Glucose intolerance reversed after the diet was stopped, though other effects may persist, according to the authors.
• The study cautions against viewing ketogenic diets as a long-term cure for metabolic disease and calls for replication and human research.