Overview
- Kick-off is 8pm BST at Anfield, with UK coverage free-to-air on ITV1/ITVX and also on Sky Sports.
- Slot has confirmed Mohamed Salah, Virgil van Dijk, Ryan Gravenberch, Ibrahima Konaté and Dominik Szoboszlai will be rested.
- Giorgi Mamardashvili and Giovanni Leoni are widely tipped to make debuts, with Alexander Isak expected to start up front.
- Thomas Bramall is the referee and VAR will not be in operation for this round.
- Liverpool arrive on a six-match winning run and lead the Premier League, while Southampton sit 19th in the Championship and have not beaten Liverpool in their last nine meetings.