Overview

• IBEC researchers combined a synthetic protein–collagen matrix with fluorescence microscopy and atomic-/raster-force tools to film blastocyst implantation in 3D real time
• The recordings show blastocysts exert measurable forces via actin–myosin protrusions to displace and remodel the uterine-like matrix during invasion
• Embryos orient their growth toward localized pressure increases, demonstrating mechanosensitive guidance in the implantation process
• Multinucleated syncytiotrophoblast precursor cells emerge and migrate outward during initial invasion, indicating early placental lineage formation
• Findings offer mechanistic insights for addressing implantation failure and improving IVF outcomes; further validation of the in vitro model is needed before clinical use