Overview

• Kickoff is Thursday at 17:00 in Peru, Ecuador and Colombia (19:00 in Brazil) at Estadio do Morumbi, with live coverage on ESPN and streaming on Disney+.
• LDU carries a 2–0 aggregate advantage from the first leg in Quito, secured by goals from Bryan Ramírez and Michael Estrada.
• São Paulo, coached by Hernán Crespo, returns home under pressure after defeats to Santos in the league and LDU in the first leg.
• Liga de Quito, led by Tiago Nunes, comes off a 4–2 LigaPro loss to Universidad Católica and has shown uneven results away from home.
• A Venezuelan officiating crew led by Alexis Herrera is reported, with Juan Soto on VAR, and some outlets suggest Palmeiras could be the semifinal opponent while others list it as to be determined.