Overview
- The trial, published in The Lancet and presented at AAIC 2026, randomized 1,065 adults aged 60–77 from 11 Latin American countries and followed them for two years.
- Participants in the structured multidomain intervention improved global cognition 55% more than those who received general health recommendations.
- Measured gains also appeared in episodic memory, attention, and executive function, which are cognitive skills sensitive to aging.
- The intervention combined supervised exercise, a locally adapted healthy diet, cardiovascular risk control, cognitive training, and group social activities, and it was led by Lucía Crivelli with funding from the Alzheimer’s Association.
- The study achieved 82.3% two-year completion and 71.6% average adherence, and investigators have started a four-year extension to test whether benefits persist without intensive support while stressing the results do not guarantee individual prevention of dementia.