Overview

• The study analyzed DNA from over 53,000 individuals with OCD and 2 million controls, identifying 30 genomic regions linked to the disorder and 249 associated genes.
• Among these, 25 genes were pinpointed as likely causal, marking the first time specific genes directly influencing OCD risk have been identified.
• The implicated genes are most active in brain regions like the hippocampus, striatum, and cerebral cortex, which are involved in decision-making, emotion regulation, and habit formation.
• Genetic overlaps were found between OCD and other conditions, including anxiety, depression, anorexia nervosa, Tourette syndrome, asthma, and migraines, suggesting shared biological pathways.
• Researchers aim to repurpose existing drugs and develop personalized treatments for OCD, leveraging these genetic discoveries to improve outcomes for patients.