Overview

• The study analyzed 15,579 ME/CFS patient genomes and 259,909 controls, identifying eight genomic regions significantly associated with the illness.
• Genetic signals involve genes linked to immune defense and neurological pathways, with two regions tied to infection responses.
• Findings, published as an unreviewed preprint, provide first robust genetic evidence for ME/CFS predisposition and aim to counter longstanding patient stigma.
• The analysis was limited to participants of European ancestry, and the DecodeME team says follow-up studies are under way to include more diverse populations.
• DecodeME researchers invite global teams to access their rich dataset for targeted studies toward diagnostic tools and treatments.