Overview

• Researchers analyzed roughly 500,000 participants’ blood using Nightingale Health NMR to quantify 249–250 metabolites and lipoprotein traits.
• Trans-ancestral analyses identified 29,824 associations across 753 genomic regions with highly similar effects across sexes and ancestry groups.
• The map highlights understudied regulators such as SIDT2, APOA1 and VEGFA, including a possible role for VEGFA in aspects of denser HDL cholesterol.
• Rare-to-common allelic series enabled assignment of effector genes at more than 100 loci and revealed extensive pleiotropy in metabolic control.
• Authors report overlap between metabolite genetic regulation and disease risk and present the atlas as a community resource for follow-up rather than immediate clinical guidance.