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Large U.S. Study Links IV Iron to Better Survival in Acute Infections With Iron-Deficiency Anemia

Authors emphasize the retrospective design, calling for randomized trials to confirm safety and benefit.

Overview

  • The analysis used a de-identified U.S. hospital database from 2000–2024 covering more than 85,000 adults hospitalized with acute bacterial infection and iron‑deficiency anemia.
  • Patients who received intravenous iron were less likely to die within 14 or 90 days and had larger hemoglobin increases than those who did not receive it.
  • The strongest survival associations were seen in pneumonia, MRSA bacteremia, and colitis, with no signal of harm across studied groups.
  • Results for bacterial meningitis were neutral, a finding the investigators attribute to the small cohort of 143 patients.
  • Findings were presented in an American Society of Hematology plenary session today, with authors noting absent details on pathogens, iron formulations, dosing, and treatment timing.