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Large Study Links Weight-Loss Surgery, Semaglutide to Lower Obesity-Related Cancer Incidence

A real-world analysis of about 180,000 adults with type 2 diabetes reports associations, not proof, linking weight-loss interventions to lower rates of several obesity-related cancers.

Overview

  • The University of Leicester team reported roughly 15% fewer cancers among people who had bariatric surgery and about 12% fewer among those prescribed semaglutide.
  • The observational study drew on real-world data for around 180,000 adults with overweight or obesity and type 2 diabetes.
  • Researchers compared cancer incidence across groups receiving semaglutide, tirzepatide, bariatric surgery, or standard diabetes medications.
  • The analysis focused on obesity-associated cancers including breast, colorectal, gallbladder, liver, ovarian, pancreatic and uterine cancers.
  • Authors emphasized the findings show associations rather than causation and called for randomized trials to confirm effects and clarify outcomes for newer drugs.