Overview

• Analysis across UK Biobank, SAIL Scotland and FinnGen found that persistent intestinal disorders were associated with up to roughly double the subsequent incidence of Alzheimer’s or Parkinson’s.
• Associations were strongest for conditions such as noninfectious colitis, gastritis, esophagitis and functional gut disorders, with signals replicated across 5, 10 and 15‑year windows.
• Polygenic risk scores indicated a lower measured genetic predisposition among patients with gut comorbidities, and proteomic profiles of Alzheimer’s and Parkinson’s cases reflected modulation by gut–brain disorders.
• The authors released an interactive resource to explore comorbidity patterns across diagnoses, genetic measures and proteins drawn from hundreds of thousands of records.
• A separate AMB Express study reported APOE4‑linked microbiota differences in healthy adults, while new mouse research showed gut immune cells migrating to the brain and fiber intake improving frailty, both warranting further validation.