Overview

• Published in Menopause, the study pooled data from more than 2 million participants and a U.S. NHANES cohort of 21,240 women.
• Hysterectomy was associated with a 9% higher stroke risk (HR 1.09), while bilateral oophorectomy was linked to a 13% increase (HR 1.13).
• Combined hysterectomy with bilateral oophorectomy showed the largest signal, with a 51% higher risk in the NHANES analysis (HR 1.55).
• A separate pooling of cohorts reported an 18% higher risk for combined surgery and a 5% increase for hysterectomy alone.
• Authors note observational limits, including self-report and possible misclassification, and call for enhanced cardiovascular risk assessment for women undergoing these procedures.