Overview

• Researchers discovered two novel genetic variants near the RAB27A and USP22 genes, linked to breast cancer in black South African women.
• This study marks the first genome-wide association study of breast cancer conducted on African women living on the continent.
• Analysis of 2,485 breast cancer patients and 1,101 controls demonstrated the inadequacy of European-derived polygenic risk scores in African populations.
• The findings underscore the unparalleled genetic diversity in African populations and the urgent need for tailored genomic tools and research investment.
• Potential applications include using the identified genes as drug targets and biomarkers to improve precision medicine and cancer treatment for African women.