Overview

• At least 60% of global liver cancer cases stem from modifiable risk factors—viral hepatitis, alcohol use and metabolic dysfunction-associated steatotic liver disease—making them largely preventable
• Without further intervention, annual new cases are expected to climb from 870,000 in 2022 to 1.52 million by 2050 and deaths from 760,000 to 1.37 million
• The share of cases linked to metabolic dysfunction-associated steatohepatitis is projected to rise from 8% to 11% and alcohol-related cases from 19% to 21%, while hepatitis B and C proportions decline
• Achieving a sustained 2–5% annual reduction in incidence could avert 9–17 million cases and save 8–15 million lives by mid-century
• The Commission’s ten recommendations include expanding hepatitis B vaccination, introducing minimum alcohol unit pricing, enhancing MASLD screening, implementing sugar taxes and bolstering lifestyle counselling