Overview
- University of Nottingham researchers developed a fluoride‑free protein gel that mimics enamel‑forming proteins to restore demineralized or eroded surfaces.
- In laboratory tests on human teeth, the gel directed epitaxial mineral growth up to about 10 micrometres within roughly a week, integrating with native enamel.
- Mechanical testing under simulated brushing, chewing, and acidic exposure indicated the regenerated layer behaved like healthy enamel.
- The material draws calcium and phosphate from saliva, can be applied in minutes in a manner similar to fluoride varnishes, and may also treat exposed dentin and improve bonding for restorations.
- The team has launched Mintech‑Bio to pursue translation, with clinical trials planned for early 2026 and a first product targeted for late 2026 subject to testing and regulatory review.