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7h ago

Kyler Murray Misses Second Straight Practice, Casting Doubt on Week 6 Start vs. Colts

He is listed day-to-day with a right-foot injury, leaving Jacoby Brissett as the likely starter if he is not cleared.

Oct 5, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) makes a throw against the Tennessee Titans during the fourth quarter at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images/ File Photo
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Kyler Murray #1 of the Arizona Cardinals exits the field during the second half of an NFL football game against the Tennessee Titans at State Farm Stadium on October 05, 2025 in Glendale, Arizona.
GLENDALE, ARIZONA - OCTOBER 05: Kyler Murray #1 of the Arizona Cardinals throws a pass during the second quarter against the Tennessee Titans at State Farm Stadium on October 05, 2025 in Glendale, Arizona. (Photo by Norm Hall/Getty Images)

Overview

  • Arizona listed Murray as a non-participant on Wednesday and Thursday, with coach Jonathan Gannon saying his status will be evaluated day to day.
  • Murray hurt his foot in the Week 5 loss to the Titans, briefly exited, then returned with a noticeable limp and adjusted mechanics.
  • A sports physician’s video review suggested a first-ray/turf‑toe–type issue in Murray’s right plant foot that could limit push-off and accuracy, indicating he could play but not at full strength.
  • If Murray cannot go Sunday in Indianapolis, veteran Jacoby Brissett would start against his former team.
  • The 2-3 Cardinals, on a three-game skid decided by last-second field goals, visit the 4-1 Colts at Lucas Oil Stadium, with Friday’s work and medical checks expected to guide Arizona’s call.