Overview

• Arizona placed Murray on the inactive list before kickoff, confirming veteran Jacoby Brissett as the starter at Lucas Oil Stadium.
• Team and league reports describe Murray’s injury as a mid-foot, Lisfranc-type sprain with aggravation risk if rushed, raising the chance of additional missed time.
• The Cardinals enter at 2-3 after three straight last-second losses and are short-handed in the backfield with James Conner out for the season and Trey Benson on injured reserve.
• Indianapolis is 4-1 with one of the NFL’s top-scoring offenses led by Daniel Jones and Jonathan Taylor, and an offensive line that has allowed a league-low four sacks.
• Game-day updates include the Colts elevating RB Ameer Abdullah, Indianapolis listing Anthony Richardson inactive after a warmups injury, and Arizona signing QB Kedon Slovis to the 53-man roster.