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1h ago

Kyler Murray Expected to Miss Colts Game With Mid-Foot Sprain as Cardinals Turn to Jacoby Brissett

NFL Network reports the injury is a Lisfranc-type sprain that could cost him more than one week.

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Oct 5, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) makes a throw against the Tennessee Titans during the fourth quarter at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images/File Photo

Overview

  • Arizona elevated Kedon Slovis to the active roster, positioning the rookie as depth behind Brissett for Week 6 in Indianapolis.
  • Multiple outlets report Brissett is expected to start, with the 10-year veteran bringing 53 career starts, including 30 with the Colts.
  • Murray was limited Friday after missing two practices, and the team is leaving a slim door open for game‑day evaluation despite plans to sit him.
  • Indianapolis enters 4-1 with Daniel Jones directing a top-scoring offense and Jonathan Taylor leading the NFL in rushing through five games.
  • Both teams adjusted special teams units as Arizona placed punter Blake Gillikin on injured reserve and signed Pat O'Donnell, while the Colts replaced injured kicker Spencer Shrader with Michael Badgley.