Overview

• Researchers discovered that the ketone body β-hydroxybutyrate (βHB) alters the solubility of misfolded proteins, enabling their clearance through autophagy.
• Experiments in mouse models of Alzheimer’s disease and aging showed reduced pathological protein aggregation and improved brain health with ketone ester treatments.
• Studies in nematode worms genetically modified to express human amyloid beta demonstrated significant recovery in mobility after ketone body treatment.
• The findings suggest ketone bodies act as signaling metabolites that regulate protein quality control and may provide new metabolic links to aging and neurodegeneration.
• The researchers propose further studies in humans to explore therapeutic applications for ketone bodies in treating neurodegenerative diseases like Alzheimer’s.