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Keratin Scaffolds Grow Enamel-Like Layer in Lab Experiments

Researchers aim to translate the scaffold into a keratin-based toothpaste following biocompatibility and durability studies in living models.

Overview

  • King’s College London scientists and international collaborators extracted keratin from hair and wool to create three-dimensional scaffolds that mineralize into an apatite-rich, enamel-like coating in vitro.
  • The peer-reviewed study in Advanced Healthcare Materials demonstrated crystal formation similar to natural enamel but did not include any animal or human trials.
  • Observed benefits include potential sealing of exposed dentine and nerve channels, suggesting a way to reduce sensitivity and protect against decay beyond traditional fluoride.
  • The keratin biomaterial is sustainably sourced from biological waste, offering a biocompatible alternative to synthetic resins used in restorative dentistry.
  • Investigators estimate 2–3 years to develop a keratin-based dentifrice, contingent on in vivo validation, long-term durability assessments and regulatory approval.