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John Mellencamp Says Daughter Teddi Is 'Really Sick' With Cancer in the Brain

The somber update on Joe Rogan follows her October report of no detectable disease during ongoing immunotherapy.

Overview

  • On the Jan. 14 episode of the Joe Rogan Experience, John Mellencamp said Teddi Mellencamp is really sick and suffering with cancer in the brain.
  • In October 2025, Teddi said scans showed no detectable cancer, clarifying she would stay on immunotherapy and was not in remission.
  • Teddi’s melanoma, first diagnosed in 2022, progressed to stage 4 in 2025 after metastasizing to her brain and lungs.
  • Her treatment has included surgeries to remove multiple brain tumors, radiation, and immunotherapy, with reports noting at least 17 melanoma lesions removed over time.
  • She previously described a roughly 50/50 survival outlook as her family, including her father, continued to provide day-to-day support and share updates through podcasts and social media.