Overview

• Jim Gaffigan has lost 50 pounds since late 2024 by administering Mounjaro injections, reducing his weight from 270 pounds to around 220 pounds.
• On the Today show, he joked that he can’t take pride in his weight loss because he was “brave enough to stick a needle” in his stomach to suppress his appetite.
• He reported significant health benefits from the weight loss, including less knee pain, reduced exhaustion and improved mobility.
• In ‘The Skinny’, Gaffigan challenges the stigma surrounding weight loss drugs and likens using injections to changing one’s hair color.
• Mounjaro, the brand name for tirzepatide, is a prescription diabetes drug given by injection that has gained traction as a medically supervised weight-loss aid.