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Jesse Williams Returns to Grey's Anatomy as Season 22 Elevates Meredith’s Research Arc

The latest episode emphasizes the research-versus-clinical focus during a season shaped by rotating cast availability.

Overview

  • Jesse Williams reprises Dr. Jackson Avery in a guest appearance centered on a plastics case at Grey Sloan.
  • Meredith Grey redirects attention to her Boston lab after raising concerns about a rival Alzheimer’s study that excluded female subjects.
  • Showrunner Meg Marinis says Meredith will split time between Boston and Seattle, expressing hope for more Seattle appearances.
  • Ellen Pompeo is expected to appear in at least seven episodes this season, with Deadline reporting her screen time could expand during the planned 18-episode run.
  • Veteran cast are working under reduced episode guarantees, and Caterina Scorsone remains on sabbatical with reports indicating her absence extends into 2026.