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3d ago

IVF Study Finds THC in Ovarian Fluid, Linking Cannabis to Fewer Chromosomally Normal Embryos

Researchers urge those trying to conceive to avoid cannabis pending larger studies.

Laut der Studie kann THC zu einer schnelleren Reifung sowie Veränderungen im Erbgut von Eizellen führen, was die Fruchtbarkeit von Frauen verringern könnte.
Der Konsum von Cannabis kann bei Frauen die Reifung und Zellteilung der Eizellen beeinträchtigen. © koya79/ iStock
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Overview

  • Published in Nature Communications, the Canadian study analyzed follicular fluid from about 1,000 IVF patients and detected THC in samples from 62 women.
  • The THC-positive group showed faster oocyte maturation and produced fewer euploid embryos suitable for IVF compared with THC-negative patients.
  • In laboratory tests, adding THC altered gene expression tied to inflammation and chromosome segregation and disrupted the spindle apparatus during cell division.
  • Experts say these mechanisms are biologically plausible pathways to aneuploidy, embryo rejection and early miscarriage, but they caution against overgeneralizing the results.
  • Clinicians note key gaps—IVF-only population, no data on dose, timing or mode of use, and no age stratification—and recommend counseling patients to avoid cannabis and standardizing questions about use in fertility care.