Overview

• The ISSCR Embryo Models Working Group published revised oversight guidelines in Stem Cell Reports.
• The guidelines urge rigorous review, clear scientific rationale, defined research timelines, elimination of the integrated versus non-integrated model distinction.
• SCBEMs replicate early human embryonic stages in three-dimensional constructs and promise new insights into development and assisted reproduction techniques.
• Australia now classifies blastocyst-like SCBEMs as equivalent to traditional embryos, while the UK gathers public input and Japan develops flexible ethical frameworks.
• Experts warn that fragmented national regulations risk hindering international collaboration and emphasize the need for distinct classification and robust informed consent processes to address moral status concerns.