Overview

• The ISSCR Embryo Models Working Group released June 2025 recommendations updating oversight for stem cell-based embryo models.
• All three-dimensional SCBEM research must undergo ethical review, present clear scientific rationale, follow defined timelines and drop the integrated versus non-integrated model distinction.
• Australia now treats blastocyst-like structures as embryos, the UK enforces codes of conduct shaped by public input and Japan is crafting adaptable ethical rules to support innovation.
• The updates respond to rapid advances in SCBEM complexity and aim to preserve public confidence in human developmental and reproductive science.
• Coordinating diverse national frameworks and ensuring informed consent for embryo-like models remain key challenges requiring multinational cooperation.