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Isomorphic Labs Nears First Human Trials of AI-Designed Drugs

The spin-off is ramping up staffing to finalize trial protocols for its AI-designed drug candidates in human testing.

In April 2025, Isomorphic Labs raised a $600 million in its first-ever external funding round, led by Thrive Capital.
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Overview

  • Isomorphic Labs is poised to begin first-in-human trials for oncology-focused candidates generated by its AlphaFold-powered AI design platform.
  • The company was spun out of Google DeepMind in 2021 following AlphaFold’s breakthrough in high-precision protein structure prediction.
  • Major research collaborations with Novartis and Eli Lilly in 2024 and a $600 million funding round led by Thrive Capital in April 2025 have underwritten its clinical push.
  • By modeling protein–ligand interactions with advanced machine learning, Isomorphic aims to shorten traditional drug development timelines and reduce costs while boosting success probabilities.
  • Initiating human testing represents a pivotal step toward realizing the company’s vision of a world-class AI-driven drug design engine.