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IPN, UACJ Advance RNAi Dengue-Mosquito Bioinsecticide Into Simulated Field Trials

The RNAi formulation blocks molting genes so Aedes aegypti larvae die before adulthood.

Overview

  • Researchers report moving from lab validation to barrel-based tests that mimic household breeding sites such as tires, buckets and containers.
  • The patent-pending product targets chitin production and the ecdysone hormonal pathway to halt larval molting.
  • Formulations include firm flakes that larvae ingest and a version that can be diluted in breeding water.
  • The team, led by Dr. Erick de Jesús de Luna Santillana with collaborator Javier Alfonso Garza Hernández, says the compound is species-specific and harmless to humans and other insects.
  • Investigators stress that community source reduction remains necessary as rainy-season conditions drive dengue risk in states including Tamaulipas, Guerrero, Jalisco, Veracruz, Morelos, Colima and the Michoacán coast.