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Intermittent Energy Restriction Shows Greatest Benefits in Diabetes Weight-Loss Trial

Presented at ENDO 2025, a 16-week trial showed intermittent energy restriction yielded the greatest fasting glucose improvements, stronger insulin sensitivity, highest adherence.

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Overview

  • All three dietary regimens delivered significant HbA1c reductions and mean weight loss of 7.5 kilograms in obese patients with type 2 diabetes.
  • Intermittent energy restriction produced the largest absolute decreases in fasting blood glucose and triglyceride levels among the three groups.
  • Participants in the intermittent energy restriction group achieved an 85% adherence rate compared with 84% for continuous energy restriction and 78% for time-restricted eating.
  • Mild hypoglycemia was rare and similarly distributed across diets, affecting two patients each in the intermittent and time-restricted groups and three in the continuous group.
  • Researchers note that these findings await peer-review and recommend further trials in diverse populations to inform clinical dietary guidelines.