Overview

• The system combines programmable light-responsive domains with AI-driven high-throughput screening to achieve millisecond temporal and micron-scale spatial control over cellular pathways
• Scientists published their findings in Cell after screening more than 370,000 compounds to selectively activate the integrated stress response
• Discovered ISR-potentiating molecules upregulate ATF4 and engage GCN2 to sensitize stressed cells to apoptosis without off-target cytotoxicity
• Lead compounds demonstrated broad-spectrum antiviral efficacy in vitro and significantly reduced disease pathology and viral titers in a mouse ocular herpesvirus model
• Integrated Biosciences is now extending the platform’s application beyond viral targets into deeper in vivo validation and discovery for age-related and other complex signaling networks