Overview

• A European Academy of Neurology study tracked 315 non-diabetic patients, including 200 with confirmed Alzheimer’s, finding those in the highest TyG index group declined four times faster over three years
• The triglyceride-glucose index is derived from routine fasting blood sugar and triglyceride readings, offering a low-cost marker available in every hospital laboratory
• High TyG scores were associated with blood–brain barrier disruption and cardiovascular risk factors but showed no interaction with APOE ε4 genotype
• Identifying insulin resistance could refine enrollment for anti-amyloid and anti-tau trials and prompt earlier lifestyle or drug interventions to slow disease progression
• Researchers are investigating whether TyG measurements align with brain imaging biomarkers to enable even earlier detection and patient stratification