Innovative Leukemia Treatment Targets Entire Blood System for Replacement

University of Basel researchers develop a method to eradicate diseased blood cells while transplanting healthy stem cells, showing promise in early studies.

• The new approach uses an antibody-drug conjugate to target and remove all blood cells marked by CD45.
• Healthy donor stem cells are genetically modified to resist the treatment, ensuring successful transplantation.
• The method aims to replace traditional chemotherapy, reducing side effects and complications.
• Initial studies in animal models and human cells have shown promising results.
• Future clinical trials are planned to further test and optimize the treatment.

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ScienceDaily GEN Nature