Overview

• Hours before kickoff, the 49ers ruled Brock Purdy and Jauan Jennings out, with Mac Jones set to start at quarterback against the Cardinals.
• Washington officially sidelined Jayden Daniels with a knee injury, installing Marcus Mariota as the starter versus the Raiders.
• Joe Burrow is out following turf-toe surgery, leaving Jake Browning to lead the Bengals on the road against the Vikings.
• The Vikings will start Carson Wentz with J.J. McCarthy out, while Harrison Smith and Christian Darrisaw are expected to play and Michael Jurgens starts at center.
• At least five teams are without their starting quarterbacks today — including the 49ers, Bengals, Vikings, Commanders and Bears — prompting widespread adjustments in projections and odds.