Overview

• Mac Jones starts for San Francisco with Brock Purdy sidelined by a turf-toe injury for the third time in four games.
• The 49ers ruled out Jauan Jennings, Ricky Pearsall and Jordan Watkins, with Brandon Aiyuk and George Kittle already on injured reserve.
• Los Angeles enters with the NFL’s ninth-ranked defense after posting 14 sacks and 20 tackles for loss through a 3–1 start.
• The Rams are a consensus 9-point favorite, with BetRivers reporting 79% of spread money on L.A. and heavy -500 moneyline support.
• Tight end Tyler Higbee and tackle Rob Havenstein are listed as doubtful for the Rams, while the 49ers’ sixth-ranked defense is without pass rusher Nick Bosa.