Overview
- San Francisco ruled out Brock Purdy, Ricky Pearsall and Jauan Jennings for Thursday night, with Mac Jones making his third start of the season after going 2-0 in Weeks 2–3.
- Los Angeles is an 8.5-point favorite and enters largely healthy, with Matthew Stafford ranking second in passing yards and Puka Nacua leading the league in receptions and receiving yards.
- The winner at SoFi Stadium will stand alone atop the NFC West, adding tiebreaker weight to the primetime matchup between 3-1 rivals.
- The 49ers’ depth is stretched with George Kittle on injured reserve and Nick Bosa out for the year, and their defense has gone 11 straight games without an interception.
- Looking ahead, the Browns will start rookie Dillon Gabriel in London against the Vikings, and Monday’s Chiefs–Jaguars matchup is widely framed as a measuring-stick test for Jacksonville.