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Injuries Shift Week 10 Odds Ahead of Multiple Top‑25 Matchups

Late injury reports have moved spreads, prompting fresh expert picks that could change College Football Playoff and Heisman resumes.

Overview

  • This weekend’s slate features several Top‑25 matchups that the CFP committee’s early rankings make especially consequential for playoff positioning and Heisman narratives.
  • Key availability news has changed game plans and lines with Miami receiver Malachi Toney ruled out, Notre Dame missing multiple defensive starters, and BYU getting LJ Martin back.
  • Sportsbooks responded to the injury and betting flow by moving spreads in several games, including Notre Dame listed as roughly a 7‑point favorite over Miami and LSU shifting toward a larger edge over Alabama in some markets.
  • National handicappers and outlets published updated picks and props reflecting the moves, including CBS Sports’ Thomas Casale backing Ohio State -7.5 and Yahoo Sports’ Week‑10 best bets such as Miami on the moneyline and a Sam Leavitt 2+ passing TDs prop.
  • Because the CFP places extra value on late‑season quality wins, the outcomes this weekend could materially alter playoff resumes and betting markets, so bettors and programs will watch injuries, in‑game trends, and live market movement closely.