Overview
- Reviewing 32,315 dermatology records, researchers compared about 2,932 tanning‑bed users with 2,925 non‑users and found melanoma in 5.1% versus 2.1%, an adjusted odds ratio of approximately 2.85.
- Single‑cell DNA sequencing of 182 melanocytes from heavy users and controls showed nearly double the mutation burden in tanning‑bed users, with a higher prevalence of melanoma‑linked mutations.
- Tanning‑associated mutations and cancers appeared on body sites typically shielded from sunlight, including the lower back and buttocks, indicating broad, field‑wide damage.
- Melanocytes from tanning‑bed users showed enrichment of mutational signature SBS11, a developing signal the authors say needs further validation to clarify its origin.
- The peer‑reviewed study, published Dec. 12 in Science Advances, has led authors to call for banning indoor tanning for minors and adding cigarette‑style warnings, with clinicians advising skin exams for former frequent users.